Methadone might cause intense hypotension which include orthostatic hypotension and syncope in ambulatory sufferers. Check in the course of initiation and/or titration of methadone.​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​�